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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T11344 | G150 | DNA , cGAS | |
G150 inhibited interferon expression triggered by DSDNA with IC50 of 10.2 nM.G150 is an effective and highly selective inhibitor of human cyclic GMP-AMP synthase (H-CGAS). | |||
T76794 | Ulocuplumab | BMS 936564,MDX 1338 | Apoptosis , CXCR |
Ulocuplumab (BMS-936564) is a fully human anti-CXCR4 IgG4 antibody.Ulocplumab exhibits antitumor activity in acute myeloid leukemia (AML), non-Hodgkin's lymphoma (NHL), and multiple myeloma transplantation models.Ulocplu... | |||
T36944 | Ara-G | Nucleoside Antimetabolite/Analog | |
Ara-G is an analog of the nucleoside guanosine and an active metabolite of nelarabine .1,2 Ara-G accumulates in T lymphoblasts and malignant T-lymphoid cells, where it is phosphorylated to produce ara-GTP and incorporate... | |||
T80737 | ZG36 | ||
ZG36, a human Caseinolytic protease P (ClpP) agonist, non-selectively degrades respiratory chain complexes and reduces mitochondrial DNA, causing mitochondrial dysfunction and inducing leukemic cell death. Additionally, ... | |||
T36681 | Sorafenib N-oxide | ||
Sorafenib N-oxide is an active metabolite of sorafenib , an inhibitor of Raf-1, B-RAF, and receptor tyrosine kinases. Sorafenib N-oxide inhibits FLT3 that contains the internal tandem duplication mutation (FLT3-ITD; Kd =... | |||
T78608 | Anticancer agent 164 | Apoptosis | |
CML-IN-1, also known as compound 7 and compound 4, is a potent anticancer agent that demonstrates a strong induced-apoptosis effect in the human chronic myeloid leukemia (CML) cell line K562. It diminishes protein phosph... | |||
T71252 | PC-046 | ||
PC-046 is a potent tubulin-binding agent, which was originally identified for development based on selective activity in deleted in pancreas cancer locus 4 (DPC4/SMAD4) deficient tumors. PC-046 has growth inhibitory acti... | |||
T73516 | EVT801 | ||
EVT801 is an orally active, selective VEGFR-3 inhibitor (IC 50 = 11 nM) with demonstrated antitumor properties. It effectively suppresses VEGF-C-induced human endothelial cell proliferation and tumor (lymphatic) angiogen... | |||
T76865 | Enavatuzumab | ||
Enavatuzumab (PDL192; ABT-361) is a humanized IgG1 monoclonal antibody designed to target the TWEAK receptor (TweakR), a protein involved in various cellular responses through its interaction with its natural ligand, TWE... | |||
T83779 | EP4 Antagonist 14 | Prostaglandin E2 Receptor 4 Antagonist 14,PGE2 Receptor 4 Antagonist 14 | |
EP4 antagonist 14 is a prostaglandin E2 receptor subtype EP4 antagonist, demonstrating an IC50 of 1.1 nM in a HEK293 human receptor reporter assay and blocking β-arrestin recruitment due to PGE2 with an IC50 of 0.9 nM. A... | |||
T35536 | Tpl2 Kinase Inhibitor (hydrochloride) | ||
Tpl2 kinase inhibitor is an inhibitor of tumor progression locus 2 (Tpl2; IC50= 0.05 μM).1It is selective for Tpl2 over MEK, p38 MAPK, Src, MK2, and PKC (IC50s = >40, 180, >400, 110, and >400 μM, respectively). Tpl2 kina... |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T34398 | Rotundifuran | Others | |
Rotundifuran is extracted from the fruit of Vitex rotundifolia. Rotundifuran inhibits cell cycle progression and induces apoptosis in human myeloid leukemia cells. | |||
T4036 | Solasodine | Solancarpidine,Purapuridine,Solasodin | Apoptosis , Others , E1/E2/E3 Enzyme , Antifungal |
Solasodine (Purapuridine)(Purapuridine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine showed selective cytotoxicity against cervical cancer cell line (HeLa) and huma... | |||
T4S1943 | Kirenol | Kirel | Wnt/beta-catenin |
1. Kirenol (Kirel) has anti-oxidant, anti-inflammatory, anti-allergic, and anti-arthritic activities. 2. Kirenol is effective against gram-positive bacteria. 3. Kirenol possesses antitumor action on human chronic myeloid... | |||
T36417 | Nargenicin | Antibiotic 47444 | |
Nargenicin is a macrolide antibiotic that selectively inhibits the growth of S. aureus, methicilin resistant S. aureus (MRSA), and M. luteus (MICs = 0.6, 0.3, and 2.5 μg/ml, respectively) over a panel of 11 Gram-positive... |
カタログ番号 | 製品名 | Species | Expression System |
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TMPJ-00042 | TSLP Protein, Human, Recombinant | Human | E. coli |
Thymic stromal lymphopoietin (TSLP) is a novel member of the hemopoietic cytokine family that promotes the development of B cells and shares overlapping activity with IL-7. The human TSLP protein comprises a 28 amino aci... | |||
TMPY-04396 | C-ABL/ABL1 Protein, Human, Recombinant (GST) | Human | Baculovirus Insect Cells |
c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cy... | |||
TMPJ-00994 | LTBR Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
It is a single-pass type I membrane protein and contains 4 TNFR-Cys repeats. The protein is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including ce... | |||
TMPH-01818 | CD200 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues. CD200 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted... | |||
TMPK-00623 | CD200R1/CRTR2 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
CD200Fc, a chimeric molecule including the extracellular domain of CD200 and a murine IgG2a Fc region, regulates immune responses following engagement of a cell surface receptor, CD200R, expressed on cells of the myeloid... | |||
TMPK-00053 | GITR Ligand/TNFSF18 Protein, Human, Recombinant (His & Flag) | Human | HEK293 Cells |
Glucocorticoid-induced TNFR-related protein (TNFRSF18, GITR, CD357), expressed by T cells, and its ligand (TNFSF18, GITRL), expressed by myeloid populations, provide co-stimulatory signals that boost T cell activity. Due... | |||
TMPK-00624 | CD200R1/CRTR2 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
CD200Fc, a chimeric molecule including the extracellular domain of CD200 and a murine IgG2a Fc region, regulates immune responses following engagement of a cell surface receptor, CD200R, expressed on cells of the myeloid... | |||
TMPK-00622 | CD200R1/CRTR2 Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells |
CD200Fc, a chimeric molecule including the extracellular domain of CD200 and a murine IgG2a Fc region, regulates immune responses following engagement of a cell surface receptor, CD200R, expressed on cells of the myeloid... | |||
TMPK-00054 | GITR Ligand/TNFSF18 Protein (Primary Amine Labeling), Human, Recombinant (His & Flag), Biotinylated | Human | HEK293 Cells |
Glucocorticoid-induced TNFR-related protein (TNFRSF18, GITR, CD357), expressed by T cells, and its ligand (TNFSF18, GITRL), expressed by myeloid populations, provide co-stimulatory signals that boost T cell activity. Due... | |||
TMPJ-01119 | GPNMB Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Osteoactivin is an intracellular glycoprotein belongs to the NMB/pMEL-17 family, which is asscociated with cell endosomal/lysomal compartments. Human Osteoactivin is a 560 amino acid type I transmembrane protein, and one... | |||
TMPJ-00305 | SIRP alpha Protein, Cynomolgus, Recombinant (aa 31-369, His) | Cynomolgus | HEK293 Cells |
Signal Regulatory Protein α (SIRPα) is a monomeric approximately 90 kD type I transmembrane glycoprotein. The 504 amino acid human SIRPα contains two Ig-like C1-type domains and one Ig-like V-type domain. SIRPα can expre... | |||
TMPY-04421 | FES Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells |
Proto-oncogene tyrosine-protein kinase Fes/Fps, also known as Proto-oncogene c-Fes, Proto-oncogene c-Fps, Feline sarcoma oncogene, FES and FPS, is a protein which contains oneFCH domain, oneprotein kinase domain and o... | |||
TMPJ-00306 | SIRP alpha Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
Signal Regulatory Protein α (SIRPα) is a monomeric approximately 90 kD type I transmembrane glycoprotein. The 504 amino acid human SIRPα contains two Ig-like C1-type domains and one Ig-like V-type domain. SIRPα can expre... | |||
TMPJ-01182 | SIRP alpha Protein, Mouse, Recombinant (MIgG2a) | Mouse | HEK293 Cells |
SIRPα is a type I transmembrane glycoprotein.It contains two Ig-like C1-type domains and one Ig-like V-type domain. Mouse SIRP alpha ECD shares 61%, 75%, 62%, 61%, and 59% aa sequence identity with human, rat, equine, bo... | |||
TMPK-00507 | TREM2 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
TREM-2 (Triggering Receptor Expressed on Myeloid cells-2) is a 35 kDa type I transmembrane member of the TREM family and Ig superfamily. Mature human TREM-2 consists of a 156 amino acid (aa) extracellular domain (ECD) w... | |||
TMPY-01401 | Cyclin A1 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
Cyclin A1 is a member of the highly conserved cyclin family that is characterized by a dramatic periodicity in protein abundance, and belongs to the A-type cyclin subfamily. The mammalian A-type cyclin family consists of... | |||
TMPJ-00018 | CCL16 Protein, Human, Recombinant | Human | E. coli |
CCL16 is a member of CC chemokine family. CCL16 cDNA encodes a 120 amino acid peptide along with a 23 amino acids signal peptide that is cleaved to generate 97 amino acid protein. CCL16 is distantly related to other CC c... | |||
TMPY-02045 | SECTM1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Secreted and transmembrane 1 (SECTM1), also known as K12, is a transmembrane and secreted protein with characteristics of a type 1a transmembrane protein of SECTM family. It is found in a perinuclear Golgi-like pattern a... | |||
TMPJ-00192 | CD32B Protein, Human, Recombinant (His) | Human | HEK293 Cells |
FcγRIIB is a low affinity receptor that recognizes the Fc portion of IgG. The human CD32 group consists of FcγRIIA, FcγRIIB, and FcγRIIC proteins that share 94-99% sequence identity in their extracellular domains but dif... | |||
TMPJ-01187 | Siglec-E Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
Siglecs are sialic acid specific I‑type lectins that are characterized by an extracellular domain (ECD) with an N‑terminal Ig‑like V‑set domain followed by varying numbers of Ig‑like C2‑set domains. Mouse Siglec‑E, also ... | |||
TMPJ-00669 | Siglec-5 Protein, Human, Recombinant (His & Flag & hFc) | Human | HEK293 Cells |
Human Siglec-5 are Itype(Igtype) lectins belonging to the Ig superfamily,They are characterized by an N terminal Ig-like V type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2 type do... | |||
TMPK-01534 | Chimeric HLA-A*02:01 (mα3) &B2M&LMP2 (CLGGLLTMV) Monomer Protein, Human&Mouse, MHC (His & Avi) | Human & Mouse | HEK293 Cells |
The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that sel... | |||
TMPK-01535 | Chimeric HLA-A*02:01 (mα3) &B2M&LMP2 (CLGGLLTMV) Tetramer Protein, Human&Mouse, MHC (His & Avi) | Human & Mouse | HEK293 Cells |
The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that sel... | |||
TMPK-01522 | Chimeric HLA-A*02:01 (mα3) &B2M&WT-1 (RMFPNAPYL) Tetramer Protein, Human&Mouse, MHC (His & Avi) | Human & Mouse | HEK293 Cells |
The WT1 protein plays a role in cell growth, the process by which cells mature to perform specific functions (differentiation), and the self-destruction of cells (apoptosis). WT1 is differentially expressed in serous, en... | |||
TMPK-01523 | Chimeric HLA-A*02:01 (mα3) &B2M&WT-1 (RMFPNAPYL) Monomer Protein, Human&Mouse, MHC (His & Avi) | Human & Mouse | HEK293 Cells |
The WT1 protein plays a role in cell growth, the process by which cells mature to perform specific functions (differentiation), and the self-destruction of cells (apoptosis). WT1 is differentially expressed in serous, en... |